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M94A2323.TXT
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1994-10-25
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Document 2323
DOCN M94A2323
TI Backcalculation using dates of HIV antibody tests.
DT 9412
AU Dietz K; Dept. of Med. Biometry, Tuebingen, Germany.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):330 (abstract no. PC0255). Unique
Identifier : AIDSLINE ICA10/94370252
AB OBJECTIVE: To estimate past incidence of HIV infection, of HIV antibody
testing and of treatment on the basis of data on AIDS incidence together
with dates of HIV antibody tests for those cases for whom a test was
performed before AIDS diagnosis and to estimate current HIV prevalence
with and without an HIV diagnosis. METHODS: The backcalculation method
is based on a Markov model for the incubation time distribution which
describes as well the transitions from infection to AIDS as through the
states not yet tested, tested, not yet treated and tested and treated.
The method is illustrated using data on AIDS cases reported to the
German Federal Office of Health in Berlin. RESULTS: The peak HIV
incidence for homosexuals, IV drug users and heterosexual contacts
occurred in 1983, 1984 and 1987, respectively. The proportion of the
overall prevalence without a test is about one third. The absolute total
prevalence at the end of 1993 is stimated between 30,000 and 40,000.
DISCUSSION AND CONCLUSION: (i) The method may be applied in other
countries where dates of tests are collected on a routine basis. (ii)
The estimates of the prevalence of treated HIV positives agree well with
the results of surveys among samples of medical practitioners.
DE Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY/TRANSMISSION AIDS
Serodiagnosis/*STATISTICS & NUMER DATA Female Germany/EPIDEMIOLOGY
Homosexuality/STATISTICS & NUMER DATA Human HIV
Infections/*EPIDEMIOLOGY/TRANSMISSION HIV Seroprevalence/TRENDS Male
Population Surveillance Substance Abuse,
Intravenous/COMPLICATIONS/EPIDEMIOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).